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New Publication in J. Org. Chem

Published on July 27, 2022 Updated on July 28, 2022

Monofunctionalized Fluorinated Bambusurils and Their Conjugates for Anion Transport and Extraction. Nicola Alessandro De Simone, Matúš Chvojka, Jana Lapešová, Luis Martínez-Crespo, Petr Slávik, Jan Sokolov, Stephen J. Butler, Hennie Valkenier* and Vladimír Šindelář*, The Journal of Organic Chemistry (2022). First published: 21 July 2022



Bambusurils are macrocyclic molecules that are known for their high binding affinity and selectivity toward anions. Here, we present the preparation of two bambusurils bearing fluorinated substituents and one carboxylic function. These monofunctionalized bambusurils were conjugated with crown ether and cholesterol units. The resulting conjugates were successfully tested in liquid–liquid extraction of inorganic salts and chloride/bicarbonate transport across lipid bilayers.