Monofunctionalized Fluorinated Bambusurils and Their Conjugates for Anion Transport and Extraction. Nicola Alessandro De Simone, Matúš Chvojka, Jana Lapešová, Luis Martínez-Crespo, Petr Slávik, Jan Sokolov, Stephen J. Butler, Hennie Valkenier* and Vladimír Šindelář*, The Journal of Organic Chemistry (2022). First published: 21 July 2022
https://doi.org/10.1021/acs.joc.2c00870
Abstract
Bambusurils are macrocyclic molecules that are known for their high binding affinity and selectivity toward anions. Here, we present the preparation of two bambusurils bearing fluorinated substituents and one carboxylic function. These monofunctionalized bambusurils were conjugated with crown ether and cholesterol units. The resulting conjugates were successfully tested in liquid–liquid extraction of inorganic salts and chloride/bicarbonate transport across lipid bilayers.