Published on September 16, 2022
– Updated on September 16, 2022
Anca-Elena Dascalu, Lau Halgreen, Aaron Torres-Huerta and Hennie Valkenier, Chemical Communications (2022). First published: 08 September 2022
https://doi.org/10.1039/D2CC03523E
Abstract
Dynamic covalent chemistry is used in many applications that require both the stability of covalent bonds and the possibility to exchange building blocks. Here we present azines as a dynamic covalent functional group that combines the best characteristics of imines and acylhydrazones. We show that azines are stable in the presence of water and that dynamic combinatorial libraries of azines and aldehydes equilibrate in less than an hour.