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New Publication: Dynamic covalent chemistry with azines

Published on September 16, 2022 Updated on September 16, 2022

Anca-Elena Dascalu, Lau Halgreen, Aaron Torres-Huerta and Hennie Valkenier, Chemical Communications (2022). First published: 08 September 2022



Dynamic covalent chemistry is used in many applications that require both the stability of covalent bonds and the possibility to exchange building blocks. Here we present azines as a dynamic covalent functional group that combines the best characteristics of imines and acylhydrazones. We show that azines are stable in the presence of water and that dynamic combinatorial libraries of azines and aldehydes equilibrate in less than an hour.